Okouchi E
Nihon Seirigaku Zasshi. 1976 Aug 1;38(8):325-35.
Snell's pituitary dwarf mice (dw) were used for studies on the relationship between hypophysis and lymphoid organs. The age-dependent changes of thymus or spleen weights of dwarf mice were compared with those of normal littermates. The suppression of growth of the thymus or spleen in dwarf mice was recognized at 5th day of age. Although involution of the thymus varied among animals, a strong positive correlation was demonstrated between relative thymus weight and body weight in 30 approximately 40 days old dwarf mice. Lymphoid organs of dwarf mice were reconstituted by injection of growth hormone and or thyroxin. Relative thymus weight significantly increased in dwarf mice when the treatment with growth hormone started at 7 days of age, but the same treatment at 3 months of age did not show any effect on the increment of relative thymus weight. On the other hand, the antibody-forming capacitiy against sheep erythrocytes of dwarf mice was significantly increased even when the treatment with growth hormone was started at 3 months of age. A marked increase in the number of lymphoid cells in dwarf mice was observed by treatment with thyroxin, even if treatment was started either at 7 days or 3 months of age. Similar changes were also obtained in the antibody-forming capacity.
斯奈尔垂体性侏儒小鼠（dw）被用于研究垂体与淋巴器官之间的关系。将侏儒小鼠胸腺或脾脏重量的年龄依赖性变化与正常同窝小鼠的进行比较。在5日龄时就发现侏儒小鼠的胸腺或脾脏生长受到抑制。尽管不同动物的胸腺退化情况有所不同，但在约30至40日龄的侏儒小鼠中，胸腺相对重量与体重之间呈现出强烈的正相关。通过注射生长激素和/或甲状腺素对侏儒小鼠的淋巴器官进行重建。当在7日龄开始用生长激素治疗时，侏儒小鼠的胸腺相对重量显著增加，但在3月龄开始相同治疗时，对胸腺相对重量的增加没有任何影响。另一方面，即使在3月龄开始用生长激素治疗，侏儒小鼠对绵羊红细胞的抗体形成能力也显著增加。用甲状腺素治疗后，无论在7日龄还是3月龄开始治疗，侏儒小鼠的淋巴细胞数量均有显著增加。在抗体形成能力方面也获得了类似的变化。
