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子宫内膜异位症与不明原因复发性自然流产:自然杀伤细胞功能异常调节导致的病理状态?

Endometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function?

作者信息

Somigliana E, Viganò P, Vignali M

机构信息

II Department of Obstetrics and Gynecology, University of Milano, Istituto Auxologico Italiano, Italy.

出版信息

Hum Reprod Update. 1999 Jan-Feb;5(1):40-51. doi: 10.1093/humupd/5.1.40.

Abstract

The observation that natural killer (NK) cell activity is abnormally low in endometriosis patients and abnormally high in women with otherwise unexplained recurrent spontaneous abortion represents, at present, an intriguing curiosity. There is evidence suggesting that these conditions are associated with an opposite regulation of NK cell behaviour. This review discusses these observations and potential relationships.

摘要

目前,自然杀伤(NK)细胞活性在子宫内膜异位症患者中异常低,而在原因不明的复发性自然流产女性中异常高,这一观察结果令人好奇。有证据表明,这些情况与NK细胞行为的相反调节有关。本文综述了这些观察结果及潜在关系。

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