Barry M K, Triplett A A, Christensen A C
School of Biological Sciences, University of Nebraska, Lincoln 68588-0118, USA.
Insect Biochem Mol Biol. 1999 Apr;29(4):319-27. doi: 10.1016/s0965-1748(99)00004-1.
We have cloned and sequenced a cDNA from Drosophila melanogaster that encodes a protein homologous to the peritrophins, a family of chitin-binding proteins from the peritrophic matrix of insects. Unexpectedly, the gene, Gasp, is expressed in the embryonic tracheae. We suggest that this family of proteins may be present in other tissues than the peritrophic matrix, particularly where nutrient or gas exchange are important, and/or where invasion by parasites or viruses is possible. We have also mapped two similar genes that had been sequenced by the Berkeley Drosophila Genome Project, and find that these three very similar genes are not clustered, but are located on three different chromosomes.
我们已经克隆并测序了来自黑腹果蝇的一个cDNA，它编码一种与围食膜蛋白同源的蛋白质，围食膜蛋白是昆虫围食膜中的一类几丁质结合蛋白家族。出乎意料的是，Gasp基因在胚胎气管中表达。我们认为，这类蛋白质可能存在于除围食膜之外的其他组织中，特别是在营养或气体交换很重要的地方，和/或在可能遭受寄生虫或病毒入侵的地方。我们还定位了两个由伯克利果蝇基因组计划测序的相似基因，发现这三个非常相似的基因并不成簇，而是位于三条不同的染色体上。
