Batko J, Witmanowski H
Department of Physiological Chemistry, University of Medical Sciences, Poznan, Poland.
Exp Toxicol Pathol. 1999 May;51(3):255-6. doi: 10.1016/s0940-2993(99)80113-4.
The activities of superoxide dismutase, glutathione peroxidase and the contents of glutathione, malondialdehyde were examined in erythrocytes of streptozotocin induced diabetic rats. The above mentioned antioxidant systems of erythrocyte were determined after treatment of diabetic rats with superoxide dismutase, trolox, catalase and allopurinol. In erythrocytes of streptozotocin induced diabetic rats the activities of superoxide dismutase, glutathione peroxidase as well as the levels of reduced glutathione were lower whereas the contents of oxidized glutathione and malondialdehyde were higher than in controls. Superoxide dismutase and trolox treatment of diabetic rats resulted in an increase of erythrocyte glutathione peroxidase activities and in reduced glutathione levels. However the levels of oxidized glutathione decreased after treatment of diabetic rats with superoxide dismutase and trolox. Catalase and allopurinol administration did not have any influence on the activities of the investigated enzymes nor on the levels of glutathione in diabetic rats. The antioxidants under study did not cause any changes in the increased level of malondialdehyde in erythrocytes.
检测链脲佐菌素诱导的糖尿病大鼠红细胞中超氧化物歧化酶、谷胱甘肽过氧化物酶的活性以及谷胱甘肽、丙二醛的含量。在用超氧化物歧化酶、生育三烯酚、过氧化氢酶和别嘌呤醇处理糖尿病大鼠后，测定上述红细胞抗氧化系统。与对照组相比，链脲佐菌素诱导的糖尿病大鼠红细胞中超氧化物歧化酶、谷胱甘肽过氧化物酶的活性以及还原型谷胱甘肽水平较低，而氧化型谷胱甘肽和丙二醛的含量较高。用超氧化物歧化酶和生育三烯酚处理糖尿病大鼠可导致红细胞谷胱甘肽过氧化物酶活性增加和还原型谷胱甘肽水平升高。然而，用超氧化物歧化酶和生育三烯酚处理糖尿病大鼠后，氧化型谷胱甘肽水平降低。给予过氧化氢酶和别嘌呤醇对糖尿病大鼠所研究酶的活性以及谷胱甘肽水平均无任何影响。所研究的抗氧化剂未引起红细胞中升高的丙二醛水平发生任何变化。
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