Kedziora-Kornatowska K Z, Luciak M, Blaszczyk J, Pawlak W
Department of Internal Diseases, Military Medical University, Lódź, Poland.
Clin Chem Lab Med. 1998 Oct;36(10):771-5. doi: 10.1515/CCLM.1998.137.
The effect of aminoguanidine (AG) on the malondialdehyde (MDA) concentration and activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) in erythrocytes of rats with streptozotocin-induced diabetes was studied. Induction of diabetes resulted in an increase of MDA concentration and decreases of SOD and catalase activities after 6 and 12 weeks. GSH-Px activity increased after 6 weeks and returned to control values after 12 weeks. AG administration did not affect body weight, blood glucose level and HbA1c content in diabetic rats but led to a decrease of MDA concentration and SOD and catalase activities after 12 weeks of treatment, with no significant effect after 6 weeks. AG attenuated the GSH-Px increase after 6 weeks but augmented the activity of this enzyme after 12 weeks. These results confirm the presence of oxidative stress in streptozotocin-induced experimental diabetes and point to the beneficial antioxidant effect of AG.
研究了氨基胍（AG）对链脲佐菌素诱导的糖尿病大鼠红细胞中丙二醛（MDA）浓度以及超氧化物歧化酶（SOD）、过氧化氢酶和谷胱甘肽过氧化物酶（GSH-Px）活性的影响。糖尿病诱导导致6周和12周后MDA浓度升高，SOD和过氧化氢酶活性降低。GSH-Px活性在6周后升高，12周后恢复到对照值。给予AG对糖尿病大鼠的体重、血糖水平和糖化血红蛋白（HbA1c）含量没有影响，但在治疗12周后导致MDA浓度以及SOD和过氧化氢酶活性降低，6周后无显著影响。AG减弱了6周后GSH-Px的升高，但增强了12周后该酶的活性。这些结果证实了链脲佐菌素诱导的实验性糖尿病中存在氧化应激，并表明AG具有有益的抗氧化作用。
