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CD34抗原表位在与慢性局灶性癫痫相关的肿瘤性和发育异常性病变中表达。

The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies.

作者信息

Blümcke I, Giencke K, Wardelmann E, Beyenburg S, Kral T, Sarioglu N, Pietsch T, Wolf H K, Schramm J, Elger C E, Wiestler O D

机构信息

Department of Neuropathology, University of Bonn Medical Center, Germany.

出版信息

Acta Neuropathol. 1999 May;97(5):481-90. doi: 10.1007/s004010051017.

Abstract

The etiology and pathogenesis of complex focal lesions associated with chronic, intractable epilepsy are largely unknown. Some data indicate that malformative changes of the central nervous system may precede the development of gangliogliomas and other epilepsy-associated neoplasms. In the present immunhistochemical study, we have examined epilepsy-associated lesions for CD34, a stem cell marker transiently expressed during early neurulation. Surprisingly, most tissue samples from patients with chronic epilepsy (n = 262) revealed neural cells immunoreactive for CD34. Prominent immunoreactivity was detected in gangliogliomas (74%), low-grade astrocytomas (62%) and oligodendrogliomas (59%). Only 52% of non-neoplastic, malformative pathologies, such as glio-neuronal hamartias or hamartomas showed solitary or small clusters of CD34-immunoreactive cells. None of the adult control tissues (n = 22), none of the specimens obtained from the developing human brain (n = 44) and none of those tumor samples from patients without epilepsy (n = 63) contained CD34-immunoreactive neural cells. However, a malignant teratoma with microscopic features of early neural differentiation displayed a focal CD34-immunoreactive staining pattern. The majority of CD34-immunoreactive cells co-localized with S-100 protein and a small subpopulation was also immunoreactive for neuronal antigens. CD34 may, thus, represent a valuable marker for the diagnostic evaluation of neoplastic and/or malformative pathological changes in epilepsy patients. The CD34 immunoreactivity of these lesions indicates an origin from dysplastic or atypically differentiated neural precursors. Further studies may elucidate the functional significance of CD34 expression during the pathogenesis of epilepsy-related focal lesions as well as during neurogenesis.

摘要

与慢性难治性癫痫相关的复杂局灶性病变的病因和发病机制在很大程度上尚不清楚。一些数据表明,中枢神经系统的畸形变化可能先于节细胞胶质瘤和其他与癫痫相关的肿瘤的发生。在本免疫组织化学研究中,我们检测了癫痫相关病变中的CD34,这是一种在早期神经胚形成过程中短暂表达的干细胞标志物。令人惊讶的是,大多数慢性癫痫患者(n = 262)的组织样本显示神经细胞对CD34呈免疫反应性。在节细胞胶质瘤(74%)、低级别星形细胞瘤(62%)和少突胶质细胞瘤(59%)中检测到显著的免疫反应性。只有52%的非肿瘤性畸形病变,如神经胶质神经元错构瘤或错构瘤,显示出孤立的或小簇的CD34免疫反应性细胞。所有成人对照组织(n = 22)、所有从发育中的人脑获得的标本(n = 44)以及所有无癫痫患者的肿瘤样本(n = 63)均未含有CD34免疫反应性神经细胞。然而,一个具有早期神经分化微观特征的恶性畸胎瘤显示出局灶性CD34免疫反应性染色模式。大多数CD34免疫反应性细胞与S-100蛋白共定位,一小部分亚群也对神经元抗原呈免疫反应性。因此,CD34可能是癫痫患者肿瘤性和/或畸形性病理变化诊断评估的一个有价值的标志物。这些病变的CD34免疫反应性表明其起源于发育异常或非典型分化的神经前体细胞。进一步的研究可能会阐明CD34在癫痫相关局灶性病变发病机制以及神经发生过程中表达的功能意义。

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