Ferlito A, Di Bonito L
ORL J Otorhinolaryngol Relat Spec. 1976;38(4):230-45. doi: 10.1159/000275279.
The present paper reports 21 cases (14 autopsies and 7 biopsies) of associated primary cancers of the larynx and the lung. This association is by no means uncommon, the laryngeal lesion being usually the first to appear. Mulitple primary cancers--of the same or of a different histologic type--tend to occur in the same organ or organ system, either simultaneously or after a time interval. In case of synchronous primary malignant tumour of the larynx and lung the most lethal cancer (the lung cancer) must be managed first. Cancer patients are more likely than other individuals to develop a second primary malignant tumour. Laryngectomized patients should be followed-up possibly by means of cytologic examinations of bronchial secretions and chest X-rays at short intervals for early detection of a possible second primary malignant pulmonary lesion.
本文报告了21例喉和肺原发性相关癌症病例（14例尸检和7例活检）。这种关联并非罕见，喉部病变通常最先出现。同一组织学类型或不同组织学类型的多发性原发性癌症倾向于在同一器官或器官系统中同时或在一段时间间隔后发生。对于喉和肺的同步原发性恶性肿瘤，必须首先处理最致命的癌症（肺癌）。癌症患者比其他个体更有可能发生第二种原发性恶性肿瘤。喉切除患者应通过对支气管分泌物进行细胞学检查并短期间隔进行胸部X光检查进行随访，以便早期发现可能的第二种原发性肺部恶性病变。
