Reddy V, Mohanram M, Raghuramulu N
Acta Paediatr Scand. 1979 Jan;68(1):65-9. doi: 10.1111/j.1651-2227.1979.tb04431.x.
Serum levels of vitamin A and retinol-binding protein (RBP) were measured in children with vitamin A deficiency, in children with protein-energy malnutrition (PEM) and in normal children, before and after administration of 100 000 IU of water-miscible vitamin A. Serum vitamin A and RBP levels were significantly low in children with vitamin A deficiency and in children with severe PEM, whereas the values in milder grades of PEM were similar to those of normal subjects. In severely malnourished children with corneal lesions, serum vitamin A concentration was reduced to a much greater extent than the level of serum RBP. Administration of vitamin A resulted in a significant increase in serum levels of both the components within 4 hours in all the 3 groups of children. The increase in RBP concentration observed in children with PEM was similar to that in vitamin A deficient children. These results indicate that in malnourished children, particularly in those who are at risk of developing keratomalacia, vitamin A is the main limiting factor. It is, therefore, recommended that children with PEM should be treated with vitamin A in addition to dietary protein and calories.
在维生素A缺乏的儿童、蛋白质 - 能量营养不良（PEM）的儿童和正常儿童中，于给予100000国际单位水溶性维生素A之前和之后测量血清维生素A和视黄醇结合蛋白（RBP）水平。维生素A缺乏的儿童和重度PEM儿童的血清维生素A和RBP水平显著降低，而轻度PEM儿童的值与正常受试者相似。在患有角膜病变的严重营养不良儿童中，血清维生素A浓度的降低程度远大于血清RBP水平。给予维生素A后，所有三组儿童的血清中这两种成分的水平在4小时内均显著升高。PEM儿童中观察到的RBP浓度升高与维生素A缺乏儿童相似。这些结果表明，在营养不良的儿童中，尤其是那些有发生角膜软化症风险的儿童，维生素A是主要的限制因素。因此，建议除了给予饮食中的蛋白质和热量外，PEM儿童还应接受维生素A治疗。
