Maskarinec G, Meng L, Shimozuma K
Cancer Research Center, University of Hawaii, Honolulu, USA.
J Epidemiol. 1999 Apr;9(2):73-7. doi: 10.2188/jea.9.73.
Mammographic density patterns, which refer to the distribution of fat, connective, and epithelial tissue in the healthy female breast, have been shown to be related to breast cancer risk. We used a quantitative method to assess mammographic densities in 41 mammograms from women in Japan without a diagnosis of breast cancer. Information about reproductive behavior and family history for breast cancer was available from a questionnaire. The statistical analysis applied Spearman correlation coefficients and multiple linear regression. The breast size as measured on the cranio-caudal view of the mammogram was approximately 12% larger, the size of the dense areas was 20% smaller, and the mean percent mammographic densities were 30% greater among premenopausal than among postmenopausal women. We found a strong relation between age at menarche and mammographic densities in premenopausal women and significant associations for age, family history of breast cancer, and age at menopause with mammographic densities in postmenopausal women. These preliminary data will be used to plan a future study that will compare mammographic density patterns and the relative importance of dietary, reproductive, and anthropometric factors between women in Japan and in the United States.
乳腺钼靶密度模式是指健康女性乳房中脂肪、结缔组织和上皮组织的分布情况，已被证明与乳腺癌风险相关。我们采用定量方法对41名未被诊断出患有乳腺癌的日本女性的乳腺钼靶密度进行了评估。通过问卷调查可获取她们的生殖行为和乳腺癌家族史信息。统计分析采用了斯皮尔曼相关系数和多元线性回归。在乳腺钼靶的头尾位视图上测量的乳房大小，绝经前女性比绝经后女性大约大12%，致密区域的大小小20%，平均乳腺钼靶密度高30%。我们发现绝经前女性初潮年龄与乳腺钼靶密度之间存在密切关系，绝经后女性的年龄、乳腺癌家族史和绝经年龄与乳腺钼靶密度之间存在显著关联。这些初步数据将用于规划未来的研究，该研究将比较日本女性和美国女性的乳腺钼靶密度模式以及饮食、生殖和人体测量因素的相对重要性。
