Bizzini B, Volpato I, Lachgar A, Cohen P, Gringeri A
Laboratoire de Physiologie Cellulaire, Université Pierre et Marie Curie, Paris, France.
Biomed Pharmacother. 1999 Mar;53(2):87-9. doi: 10.1016/s0753-3322(99)80064-x.
Antiviral therapy, including antiprotease treatment, suppresses viral replication, but it does not restore the HIV-1 induced immunopathogenesis which includes IFN alpha overproduction and cellular immunosuppression. To combat HIV-1 induced immunopathogenesis, anti-IFN alpha kinoid immunization in combination with tritherapy may be beneficial to HIV-1 infected immunodeficient patients.
抗病毒疗法,包括抗蛋白酶治疗,可抑制病毒复制,但无法恢复HIV-1诱导的免疫发病机制,其中包括干扰素α过度产生和细胞免疫抑制。为对抗HIV-1诱导的免疫发病机制,抗干扰素α类激肽免疫与三联疗法联合使用可能对HIV-1感染的免疫缺陷患者有益。