Honda M, Yasuoka A, Aoki M, Oka S
AIDS Clinical Center, the International Medical Center of Japan, Tokyo.
Intern Med. 1999 Mar;38(3):302-3. doi: 10.2169/internalmedicine.38.302.
Nelfinavir, one of human immunodeficiency virus (HIV) specific protease inhibitors(PIs), is widely used for the treatment of HIV infection. Nelfinavir, which is metabolized with the cytochrome p450 isoforms, elevate the phenytoin level theoretically because nelfinavir acts as an inhibitor of phenytoin metabolism through the enzyme. However, we encountered a case of seizure recurrence caused by a lowered phenytoin level after initiation of nelfinavir. We should be aware of the change in the phenytoin level in concomitant use of nelfinavir.
奈非那韦是一种人类免疫缺陷病毒（HIV）特异性蛋白酶抑制剂（PIs），广泛用于治疗HIV感染。奈非那韦经细胞色素P450同工酶代谢，理论上会提高苯妥英水平，因为奈非那韦通过该酶抑制苯妥英代谢。然而，我们遇到了一例在开始使用奈非那韦后因苯妥英水平降低导致癫痫复发的病例。在同时使用奈非那韦时，我们应注意苯妥英水平的变化。
