Alleyne C H, He J, Yang J, Hunter S B, Cotsonis G, James C D, Olson J J
Barrow Neurologic Institute, Phoenix, AZ 85013, USA.
Int J Oncol. 1999 Jun;14(6):1111-6. doi: 10.3892/ijo.14.6.1111.
The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.
研究人脑中以及脑肿瘤中的细胞周期蛋白依赖性激酶抑制剂p16、p21和p27，以探索其与临床病理的相关性。进行了蛋白质免疫印迹分析和免疫组织化学检测，并与患者的临床特征进行回顾性关联分析。发现无进展生存期延长与p27表达之间存在一种趋势。p27表达与年龄或性别之间无相关性。p27在恶性胶质瘤中的表达可能具有预后价值。此外，鉴于有报道称表达p27的肿瘤恶性潜能降低，因此有必要研究这种细胞周期蛋白依赖性激酶抑制剂过表达的治疗益处。
