Polansky S M, Barwick K W, Ravin C E
AJR Am J Roentgenol. 1979 Jan;132(1):17-21. doi: 10.2214/ajr.132.1.17.
Four new cases of primary mediastinal seminoma are presented, and the 103 previously reported cases reviewed. All of the tumors occurred in the anterior mediastinum, and generally appeared as lobulated noncalcified masses on chest radiography. Most patients were in the third and fourth decades, and about 30% were asymptomatic at the time of initial diagnosis. Although mediastinal seminoma is not commonly considered a cause of superior vena caval obstruction, about 10% of patients experience it. The tumors are radiosensitive and potentially radiocurable. A striking reduction in size of the tumor may be noted after radiation therapy. Prognosis is generally good, with a 5-year survival rate of 75%. The controversy surrounding histogenesis of this tumor is reviewed, and the pathologic criteria for making the diagnosis presented.
本文报告了4例原发性纵隔精原细胞瘤的新病例，并对之前报告的103例病例进行了回顾。所有肿瘤均发生在前纵隔，胸部X线检查通常表现为分叶状非钙化肿块。大多数患者年龄在第三和第四个十年，约30%的患者在初诊时无症状。虽然纵隔精原细胞瘤通常不被认为是上腔静脉阻塞的原因，但约10%的患者会出现这种情况。肿瘤对放疗敏感，有可能通过放疗治愈。放疗后可观察到肿瘤大小显著缩小。总体预后良好，5年生存率为75%。本文回顾了围绕该肿瘤组织发生的争议，并提出了诊断的病理标准。
