Dorizzi R M, Senna G, Caputo M
Laboratorio Analisi Chimico Cliniche ed Ematologiche, Azienda Ospedaliera di Verona, Italy.
Clin Chim Acta. 1999 Apr;282(1-2):175-83. doi: 10.1016/s0009-8981(99)00027-3.
The relevance of latex allergy has greatly increased in the last decade especially in health workers and in children with spina bifida. Serological testing has been proposed in the diagnosis since history can be inconclusive and skin and provocative testing can induce severe adverse reactions. We evaluated positive likelihood ratios (LRpos) and the Fagan's nomogram in the diagnosis of latex allergy. Thirty patients with positive clinical history, who showed positive results in the skin prick test and in glove-exposure test were compared to 36 blood donors with negative clinical history, who showed negative results in the skin prick test and in glove-exposure test. LRpos was calculated at four different cutoff concentrations of IgE specific to latex measured with a totally automated analyzer. LRs appear better compared to the traditional classes in the reporting of IgE and, coupled with the Fagan's nomogram which allows the calculation of post-test probability, could improve laboratory testing in latex allergy.
在过去十年中，乳胶过敏的相关性显著增加，尤其是在医护人员和患有脊柱裂的儿童中。由于病史可能不明确，且皮肤和激发试验可能引发严重不良反应，因此血清学检测已被用于诊断。我们评估了乳胶过敏诊断中的阳性似然比（LRpos）和费根氏诺模图。将30例临床病史阳性、皮肤点刺试验和手套接触试验结果为阳性的患者与36例临床病史阴性、皮肤点刺试验和手套接触试验结果为阴性的献血者进行比较。使用全自动分析仪在四个不同的乳胶特异性IgE截断浓度下计算LRpos。与传统的IgE分类报告相比，似然比似乎更好，并且结合允许计算检验后概率的费根氏诺模图，可以改善乳胶过敏的实验室检测。
