糖苷酶的同位素编辑核磁共振研究：一种新型糖苷酶抑制剂的设计与合成
Isotope edited NMR studies of glycosidases: design and synthesis of a novel glycosidase inhibitor.
作者信息
Hines J V, Chang H, Gerdeman M S, Warn D E
机构信息
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus 43210, USA.
出版信息
Bioorg Med Chem Lett. 1999 May 3;9(9):1255-60. doi: 10.1016/s0960-894x(99)00175-4.
Abstract
N-13C-methyl-deoxynojirimycin was synthesized and used in isotope-edited NMR studies to probe the binding site of an alpha-glucosidase. Results from this analysis led to the design and preparation of a novel alpha-glucosidase inhibitor, N-glycyl deoxynojirimycin.
摘要
合成了N-13C-甲基-脱氧野尻霉素，并将其用于同位素编辑核磁共振研究，以探究α-葡萄糖苷酶的结合位点。该分析结果促成了新型α-葡萄糖苷酶抑制剂N-甘氨酰脱氧野尻霉素的设计与制备。
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