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[心房颤动的射频导管消融术的最新进展]

[Recent advances in radiofrequency catheter ablation for atrial fibrillation].

作者信息

Ohnishi S, Kasanuki H

机构信息

Department of Cardiology, Kanto Teishin Hospital, Tokyo.

出版信息

J Cardiol. 1999 Mar;33 Suppl 1:71-7.

Abstract

Failure to control the ventricular rate in atrial fibrillation (AF) can be treated by radiofrequency (RF), ablation or modification of atrioventricular (AV) node. AV nodal ablation with pacemaker and AV nodal modification are associated with significant improvement in symptoms and quality of life. But there is no evidence that these techniques influence survival, and in some cases these therapies must be followed by implantation of a permanent pacemaker (due to complete AV block), and anticoagulation (due to persistence of underlying AF). The maze operation attempts to abolish AF by channeling the atrial activation between a series of incisions. Early results are encouraging, and simultaneous surgery may be beneficial. RF ablation can be used to create long linear lesions for this purpose (catheter maze). Preliminary studies show a higher success rate when linear ablations are performed in the left atrium than in the right atrium and that arrhythmogenic foci play a significant role in atrial fibrillation. However, catheter mazes are prolonged, and it is difficult with current technology to create endocardial linear lesions consistently that act as barriers to conduction. It is required to optimize this to transform investigational technique into a routine procedure. In specific cases, focal ablation or catheter ablation of the right atrial only can prevent AF. It may be possible that different approaches of ablation may be required, depending on the etiology. Curative radiofrequency catheter ablation for patients with AF may not be far in the future.

摘要

房颤时心室率控制不佳可通过射频(RF)、房室(AV)结消融或改良来治疗。房室结消融加起搏器植入以及房室结改良可使症状和生活质量显著改善。但尚无证据表明这些技术会影响生存率,而且在某些情况下,这些治疗之后必须植入永久性起搏器(因完全性房室传导阻滞)以及进行抗凝治疗(因潜在房颤持续存在)。迷宫手术试图通过在一系列切口之间引导心房激动来消除房颤。早期结果令人鼓舞,同期手术可能有益。为此,射频消融可用于制造长线性损伤(导管迷宫术)。初步研究表明,在左心房进行线性消融的成功率高于右心房,而且致心律失常灶在房颤中起重要作用。然而,导管迷宫术操作时间长,而且以目前的技术难以持续制造出作为传导屏障的心内膜线性损伤。需要对此进行优化,以便将研究性技术转变为常规手术。在特定情况下,仅对右心房进行局灶性消融或导管消融可预防房颤。根据病因不同,可能需要采用不同的消融方法。对房颤患者进行根治性射频导管消融术可能为期不远了。

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