链脲佐菌素对大鼠各组织中谷胱甘肽和脂质过氧化物水平的影响。

Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats.

作者信息

Baştar I, Seçkin S, Uysal M, Aykaç-Toker G

机构信息

Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.

出版信息

Res Commun Mol Pathol Pharmacol. 1998 Dec;102(3):265-72.

PMID:10342913

Abstract

In this study, the effect of streptozotocin (STZ) on lipid peroxidation and glutathione (GSH) content was investigated in the liver, pancreas and kidney of rats. Lipid peroxide levels were significantly increased in homogenates and mitochondrial fractions of the liver, kidney and pancreas after STZ administration. GSH levels in hepatic and pancreatic tissues were decreased but unchanged in the kidney of diabetic rats. GSH content in hepatic mitochondrial fraction was also decreased compared to control group. On the other hand, the destruction of pancreatic beta-cells was also observed histopathologically. Our results indicate that oxidative stress may play an important role in STZ induced diabetes and mitochondrial fraction may be the target in this toxicity.

摘要

在本研究中，研究了链脲佐菌素（STZ）对大鼠肝脏、胰腺和肾脏脂质过氧化及谷胱甘肽（GSH）含量的影响。给予STZ后，肝脏、肾脏和胰腺的匀浆及线粒体组分中的脂质过氧化物水平显著升高。糖尿病大鼠肝脏和胰腺组织中的GSH水平降低，但肾脏中的GSH水平未发生变化。与对照组相比，肝脏线粒体组分中的GSH含量也降低。另一方面，组织病理学检查也观察到胰腺β细胞的破坏。我们的结果表明，氧化应激可能在STZ诱导的糖尿病中起重要作用，线粒体组分可能是这种毒性作用的靶点。