Leis H J, Fauler G, Raspotnig G, Windischhofer W
University Childrens Hospital, Dept. of Biochemical Analysis and Mass Spectrometry, University of Graz, Austria.
Rapid Commun Mass Spectrom. 1999;13(8):650-3. doi: 10.1002/(sici)1097-0231(19990430)13:8<650::aid-rcm536>3.0.co;2-x.
An improved method for the quantitative measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives.
本文提出了一种改进的定量测定人血浆中血管紧张素转换酶抑制剂赖诺普利的方法。该测定基于气相色谱/负离子化学电离质谱法。该方法包括在C18吸附剂上进行固相萃取,并衍生化为五氟苄基二酯三氟乙酰胺衍生物。