Nagore E, Díaz F, Sánchez-Motilla J M, Prats A, García-Castell J, Aliaga A
Department of Dermatology, Hospital General Universitario, Valencia, Spain.
J Dermatol. 1999 Apr;26(4):253-7. doi: 10.1111/j.1346-8138.1999.tb03467.x.
A 69-year-old woman had a well-defined, slightly raised, brownish, keratotic plaque with an eccentric group of roughly circular, bluish, dome nodules on her right scapular area. Histological study revealed the presence of an eccrine poroma demonstrating features of eccrine poroma, hidroacanthoma simplex, and dermal duct tumor and arising in a lesion of seborrheic keratosis and a trichoepithelioma. In the eccrine poroma region, an area with malignant changes was evident. The findings in this case support the view of eccrine poroma as a spectrum of histological variants and the possibility of malignant transformation from a eccrine poroma towards porocarcinoma. The association with seborrheic keratosis is most probably coincidental, and the trichoepithelioma was probably due to induction of the tumoral stroma on adjacent follicular epithelia.
一名69岁女性右侧肩胛区有一个边界清晰、略隆起、褐色的角化性斑块，斑块上有一组偏心分布的大致圆形、蓝色、圆顶状小结节。组织学研究显示存在一个小汗腺汗孔瘤，其表现出小汗腺汗孔瘤、单纯性汗腺棘皮瘤和皮肤导管瘤的特征，且发生于脂溢性角化病和毛发上皮瘤的病变中。在小汗腺汗孔瘤区域，可见有恶变改变的区域。该病例的发现支持小汗腺汗孔瘤是一系列组织学变异的观点，以及小汗腺汗孔瘤向汗孔癌恶变的可能性。与脂溢性角化病的关联很可能是巧合，而毛发上皮瘤可能是由于肿瘤基质对相邻毛囊上皮的诱导所致。
