前列腺癌和良性前列腺增生患者雄激素受体表达与FGF8 mRNA水平的相关性
Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy.
作者信息
Wang Q, Stamp G W, Powell S, Abel P, Laniado M, Mahony C, Lalani E N, Waxman J
机构信息
Department of Histopathology, Imperial College School of Medicine, London, UK.
出版信息
J Clin Pathol. 1999 Jan;52(1):29-34. doi: 10.1136/jcp.52.1.29.
AIM
To investigate the correlation between androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels.
METHODS
39 human prostate cancers and 14 benign prostatic hypertrophy specimens were examined immunohistochemically for androgen receptor expression and by in situ hybridisation and reverse transcription polymerase chain reaction for FGF8 expression.
RESULTS
In 39 tumours there was a statistically significant negative correlation between tumour grade and FGF8 expression and a positive correlation between FGF8 and androgen receptor expression. All 14 benign hypertrophy specimens expressed moderate to high levels of FGF8 and androgen receptor.
CONCLUSIONS
Loss of FGF8 may be a factor involved in the development of prostatic cancer.
目的
研究雄激素受体表达与成纤维细胞生长因子8（FGF8）mRNA水平之间的相关性。
方法
对39例人类前列腺癌和14例良性前列腺增生标本进行免疫组织化学检测雄激素受体表达，并通过原位杂交和逆转录聚合酶链反应检测FGF8表达。
结果
在39例肿瘤中，肿瘤分级与FGF8表达之间存在统计学上的显著负相关，FGF8与雄激素受体表达之间存在正相关。所有14例良性增生标本均表达中至高水平的FGF8和雄激素受体。
结论
FGF8缺失可能是前列腺癌发生发展的一个相关因素。
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