恶性肿瘤分级系统、DNA含量、p53及血管生成对Ⅰ期舌癌的预测价值
Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for stage I tongue carcinomas.
作者信息
Högmo A, Kuylenstierna R, Lindholm J, Munck-Wikland E
机构信息
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska Hospital, Stockholm, Sweden.
出版信息
J Clin Pathol. 1999 Jan;52(1):35-40. doi: 10.1136/jcp.52.1.35.
AIM
To assess the clinical value of malignancy grading systems compared with nuclear DNA content, protein p53, and angiogenesis for predicting recurrence of stage I (UICC, 1987) tongue carcinomas.
METHODS
Histopathological malignancy grading according to Jakobsson and tumour front grading according to Bryne et al were performed on haematoxylin and eosin slides. DNA analysis was performed by image cytometry. Protein p53 and angiogenesis were evaluated by immunohistochemical analysis using antibody CM1 and antibody against factor VIII related antigen, respectively.
RESULTS
49 patients with stage I carcinomas of the mobile tongue were included, all treated by local surgical excision alone. Eight patients (16%) suffered from local recurrence during follow up, and 13 (27%) had regional recurrence. Both Jakobsson's malignancy grading system and p53 immunoreactivity proved to be useful predictors of regional recurrence in a Cox multivariate regression analysis.
CONCLUSIONS
Histopathological malignancy grading systems provide valuable prognostic information and can still compete with current biological markers in this respect.
目的
评估恶性肿瘤分级系统与核DNA含量、蛋白p53及血管生成在预测国际抗癌联盟（UICC，1987）I期舌癌复发方面的临床价值。
方法
在苏木精-伊红染色切片上，按照雅各布森方法进行组织病理学恶性分级，按照布赖内等人的方法进行肿瘤前沿分级。通过图像细胞术进行DNA分析。分别使用抗体CM1和抗VIII因子相关抗原抗体，通过免疫组织化学分析评估蛋白p53和血管生成。
结果
纳入49例I期活动期舌癌患者，均仅接受局部手术切除治疗。8例患者（16%）在随访期间出现局部复发，13例（27%）出现区域复发。在Cox多变量回归分析中，雅各布森恶性分级系统和p53免疫反应性均被证明是区域复发的有用预测指标。
结论
组织病理学恶性分级系统提供了有价值的预后信息，在这方面仍可与当前的生物标志物相媲美。
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