Svinogeeva T P, Konopliannikov A G, Shtein L V
Vopr Onkol. 1976;22(9):62-6.
Under study was the kinetics of growth of cervical cancer (CCM-1) transplanted on mice CBA, also the mitotic cycle and diurnal activity of tumor cells division. The tumor growth can well be described with the Hompertz equation, the constants of acceleration and retardation being equal to 0.34 day-1 and 0.004 day-1 accordingly. A linear dependence between the size, weight and number of CCM-1 celos is shown. In the tumor under study a persistant diurnal rhythm of the cell division was found with the maximum at 7 and 19 hours and the minimum at 13. The basis parameters of the mitotic cycle of tumor cells were determined: Tc=17.8 hr., G2 approximately 40 min.; S=9 hr., M approximately 24 min., G1 approximately 18.4 hr. The time of tumor doubling was 48.7 hr. The cell loss factor is as much as 42.1 per cent.
研究了移植于CBA小鼠的子宫颈癌（CCM - 1）的生长动力学，以及肿瘤细胞分裂的有丝分裂周期和昼夜活动。肿瘤生长可用霍姆珀兹方程很好地描述，加速常数和减速常数分别等于0.34天⁻¹和0.004天⁻¹。结果表明CCM - 1细胞的大小、重量和数量之间存在线性关系。在所研究的肿瘤中发现了持续的昼夜细胞分裂节律，在7时和19时达到最大值，在13时达到最小值。确定了肿瘤细胞有丝分裂周期的基本参数：Tc = 17.8小时，G2约40分钟；S = 9小时，M约24分钟，G1约18.4小时。肿瘤倍增时间为48.7小时。细胞丢失率高达42.1%。
