Grabarević Z, Dzaja P, Perić J, Serman V, Bidin Z, Mazija H, Mas N, Mikulec Z, Culjak K, Simec Z, Njari B
Faculty of Veterinary Medicine, University of Zagreb, Republic of Croatia.
Acta Vet Hung. 1999;47(2):233-41. doi: 10.1556/004.47.1999.2.8.
The work describes the effects of cimetidine on stress-induced gizzard erosions (Experiment A) and the influence of the long-term application (42 days) of the same drug on weight gain and feed consumption during broiler fattening (Experiment B). For Experiment A, 60 male, three-day-old chicks were divided into two groups: C (n = 30)--control chicks treated with 0.5 ml saline; CIM (n = 30)--chicks treated with cimetidine in a dose of 5 mg/kg body weight (b. w.) intragastrically. All chicks were stressed using a modified water-immersion stress method according to which the chicks, after 24 h of feed deprivation, were immersed in tap water (17 degrees C) for a few seconds. Under chloroform anaesthesia ten chicks from each group were killed 1, 2 and 3 h after the stressing. The morphometric analysis of gizzard erosion (GE) and histopathological examinations of gizzards were performed for each chick. In Experiment B, 32 one-day-old broilers of both sexes were used. The control group was untreated (n = 16) while the CIM group (n = 16) was fed the same diet supplemented with 10 mg of cimetidine per kilogram of feed throughout the fattening period (42 days). The results of Experiment A showed decreased mean length of the GE in the cimetidine-treated birds as compared with the GE lesions of the controls. In Experiment B, the treated chicks had reduced liveweight (1835.1 g), carcass weight (1474.6 g) and increased feed consumption (2115 g of feed per kilogram of weight gain) compared to the controls in which the same parameters were 1898.5 g, 1574.2 g and 1797 g, respectively. The results show that while stress-induced GE of chicks can be medicated pharmacologically, long-term application of the same substance impairs the results of fattening.
这项研究描述了西咪替丁对应激诱导的肌胃糜烂的影响（实验A），以及同一药物长期应用（42天）对肉鸡育肥期间体重增加和采食量的影响（实验B）。对于实验A，将60只3日龄雄性雏鸡分为两组：C组（n = 30）——用0.5毫升生理盐水处理的对照雏鸡；CIM组（n = 30）——以5毫克/千克体重的剂量通过胃内给药西咪替丁的雏鸡。所有雏鸡均采用改良的水浸应激方法进行应激处理，即雏鸡在禁食24小时后，浸入自来水（17摄氏度）中几秒钟。在氯仿麻醉下，应激处理后1小时、2小时和3小时，每组处死10只雏鸡。对每只雏鸡进行肌胃糜烂（GE）的形态计量分析和肌胃的组织病理学检查。在实验B中，使用了32只1日龄的雌雄肉鸡。对照组未进行处理（n = 16），而CIM组（n = 16）在整个育肥期（42天）喂食添加了每千克饲料10毫克西咪替丁的相同日粮。实验A的结果显示，与对照组的GE损伤相比，西咪替丁处理组的GE平均长度有所缩短。在实验B中，与对照组相比，处理组雏鸡的活重（1835.1克）、胴体重（1474.6克）降低，采食量增加（每千克体重增加消耗2115克饲料），而对照组的相同参数分别为1898.5克、1574.2克和1797克。结果表明，虽然雏鸡应激诱导的GE可以通过药物治疗，但同一物质的长期应用会损害育肥效果。
