Bilińska M, Frydecka I, Podemski R
Katedry i Kliniki Neurologii AM we Wrocławiu.
Pol Merkur Lekarski. 1999 Jan;6(31):23-6.
The levels of sIL-2R alpha, sICAM-1, and sVCAM-1 in sera of patients with clinically probable multiple sclerosis (ms) during the first relapse were assessed. In ms patients the levels of these 3 soluble molecules were significantly increased in comparison with the results obtained in controls. The results reflected activation of lymphocytes T and enhancement expression of adhesion molecules on brain endothelial cells, therefore they could serve indirectly as markers of immunological activation in multiple sclerosis. Any of the levels of soluble molecules in sera did not correlate with the severity of the disease.
对临床疑似多发性硬化症（MS）患者首次复发期间血清中可溶性白细胞介素-2受体α（sIL-2Rα）、可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）的水平进行了评估。与对照组结果相比，MS患者血清中这三种可溶性分子的水平显著升高。这些结果反映了T淋巴细胞的激活以及脑内皮细胞上黏附分子表达的增强，因此它们可间接作为多发性硬化症免疫激活的标志物。血清中任何一种可溶性分子的水平均与疾病严重程度无关。
