Potemski P, Płuzańska A
Zakładu Farmakologii Akademii Medycznej w Lodzi.
Pol Merkur Lekarski. 1999 Jan;6(31):27-9.
Paclitaxel (taxol, Tax) is a novel plant product isolated from the Pacific yew (Taxus brevifolia). It has a unique mechanism of action, because it induces very stable and dysfunctional microtubules. Paclitaxel has a broad spectrum of antineoplastic activity. It has been successfully used in the treatment of ovarian cancer, metastatic breast cancer, lung cancer, carcinoma of the head and neck, malignant melanoma and other human neoplasms. Tax has response rates of 20-36% in patients with refractory ovarian cancer. Toxic effects include myelosuppresion, hypersensitivity reactions, peripheral neuropathy, cardiac disturbances, alopecia. However, studies evaluating the drug still are ongoing paclitaxel seems to be one of the most promising antineoplastic agents.
紫杉醇（泰素，Tax）是从太平洋紫杉（短叶红豆杉）中分离出的一种新型植物产物。它具有独特的作用机制，因为它能诱导形成非常稳定且功能异常的微管。紫杉醇具有广泛的抗肿瘤活性。它已成功用于治疗卵巢癌、转移性乳腺癌、肺癌、头颈癌、恶性黑色素瘤及其他人类肿瘤。对于难治性卵巢癌患者，紫杉醇的缓解率为20% - 36%。其毒性作用包括骨髓抑制、过敏反应、周围神经病变、心脏功能紊乱、脱发。然而，对该药物的评估研究仍在进行中，紫杉醇似乎是最有前景的抗肿瘤药物之一。
