Pagani M, Baig H, Sherman A, Manders W T, Quinn P, Patrick T, Franklin D, Vatner S F
Am J Physiol. 1978 Nov;235(5):H610-7. doi: 10.1152/ajpheart.1978.235.5.H610.
This paper describes the development of several important modifications that were incorporated into the ultrasonic, transit-time dimension system in order to obtain multiple simultaneous, instantaneous, and continuous measurements of the external dimensions of the aorta and its major branches in conscious, unrestrained animals. At operation a pair of small piezoelectric crystals was sutured to arterial adventitia, and a miniature pressure gauge was implanted in the vessel at the same cross-sectional plane. After recovery from surgery, wall motion was not altered appreciably and scarring was minimal. This technique allows long-term monitoring of aortic pressure-dimension relations and is applicable for small (fetal and neonatal) as well as large (adult dogs and sheep) animals. When vessel wall thickness is measured, stress-radius analysis can be performed so as to compute vascular elastic stiffness as a function of stress. Moreover, the suitability for radiotelemetry of the pressure and dimension signals measured with this technique enables the study of these parameters in unrestrained animals, e.g., during spontaneous severe exercise.
本文描述了对超声传播时间尺寸系统进行的几项重要改进，以便在清醒、不受约束的动物身上同时获得主动脉及其主要分支外部尺寸的多个同步、瞬时和连续测量值。手术时，将一对小型压电晶体缝合到动脉外膜上，并在同一横截面上将一个微型压力计植入血管中。术后恢复后，血管壁运动没有明显改变，瘢痕形成最小。该技术可长期监测主动脉压力-尺寸关系，适用于小型（胎儿和新生儿）以及大型（成年犬和绵羊）动物。测量血管壁厚度时，可以进行应力-半径分析，以便计算血管弹性刚度与应力的函数关系。此外，该技术测量的压力和尺寸信号适用于无线电遥测，从而能够在不受约束的动物身上研究这些参数，例如在自发剧烈运动期间。
