小鼠胎儿发育：卵黄囊红细胞终末分化过程中珠蛋白基因的翻译失活。
Mouse foetal development: translational inactivation of globin genes during the terminal differentiation of yolk sac erythroid cells.
作者信息
Fantoni A, Ullu E, Gambari R, Lunadei M, Farace M G
出版信息
Ann Immunol (Paris). 1976 Nov-Dec;127(6):881-6.
PMID:1034464
Abstract
The molecular mechanism of globin genes inactivation has been explored at the translational level in yolk sac erythroid cells from mouse foetuses. Ageing of the messenger molecules is paralleled by a progressive decrease of the poly(A) tail. Poly(A) less messengers are less active when tested in a wheat germ cell free system and become uncapable to terminate globin chain elongation.
摘要
在小鼠胎儿卵黄囊红细胞中，已在翻译水平上探索了珠蛋白基因失活的分子机制。信使分子的老化与聚腺苷酸（poly(A)）尾巴的逐渐缩短平行。在小麦胚芽无细胞系统中进行测试时，聚腺苷酸较少的信使分子活性较低，并且无法终止珠蛋白链的延伸。
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