Stutman O
Ann Immunol (Paris). 1976 Nov-Dec;127(6):943-9.
The migration of CBA/HT6T6 haemopoietic cells (adult bone marrow, embryonic liver or yolk sac) to established thymus grafts, in CBA/H 60-day neonatally thymectomized hosts, shows that all three cell types can migrate and divide within the grafts, albeit yolk sac cells appear later after cell injection. This last observation suggested possible intermediate steps, i.e. a sojourn in bone marrow (or liver in the embryos). When the same experiments were performed in hosts that had been pre-treated with 100 muCi of 89Sr (a bone seeking isotope), it was observed that marrow and embryonic liver cells still could migrate to thymus and subsequently generate a population of competent T lymphocytes, while yolk sac cells were incapable of such migration.
将CBA/HT6T6造血细胞（成体骨髓、胚胎肝脏或卵黄囊）移植到新生60天经胸腺切除的CBA/H宿主中已建立的胸腺移植物中，结果显示所有这三种细胞类型都能在移植物中迁移和分裂，尽管卵黄囊细胞在注射后出现得较晚。这一最后的观察结果提示了可能的中间步骤，即在骨髓（或胚胎中的肝脏）中停留。当在预先用100微居里的89Sr（一种亲骨性同位素）处理过的宿主中进行相同实验时，观察到骨髓和胚胎肝细胞仍能迁移到胸腺并随后产生一群有功能的T淋巴细胞，而卵黄囊细胞则无法进行这种迁移。
