Sauerwein H P, Romijn J A
Afd. Endocrinologie en Metabolisme, Academisch Medisch Centrum/Universiteit van Amsterdam.
Ned Tijdschr Geneeskd. 1999 Apr 24;143(17):886-9.
Weight loss is an independent risk factor for mortality in chronically ill weight-losing patients. Hunger strikers and chronically ill patients die after a weight loss of about 40%; weight loss is strongly correlated with loss of lean body mass. Lean body mass is determined by protein synthesis and protein breakdown. Increased supply of amino acids diminishes loss of lean body mass. It is advisable to increase the protein content of the diet of chronically ill weight-losing patients to the level that maximally stimulates protein synthesis, i.e. 1.5 g protein/kg/day.
体重减轻是慢性病体重减轻患者死亡的独立危险因素。绝食者和慢性病患者在体重减轻约40%后死亡;体重减轻与瘦体重的丧失密切相关。瘦体重由蛋白质合成和蛋白质分解决定。增加氨基酸供应可减少瘦体重的丧失。建议将慢性病体重减轻患者饮食中的蛋白质含量提高到能最大程度刺激蛋白质合成的水平,即1.5克蛋白质/千克/天。