Milner S M, Heggers J P
Institute for Plastic and Reconstructive Surgery, Southern Illinois University of School of Medicine, Springfield, USA.
Wilderness Environ Med. 1999 Spring;10(1):10-2. doi: 10.1580/1080-6032(1999)010[0010:tuoamd]2.3.co;2.
We report the first clinical use of a modified Dakin's solution (0.025% sodium hypochlorite [NaOCl]) to halt the progress of severe cutaneous Vibrio vulnificus infection in a critically ill patient. The regimen used arose from an initial in vitro study designed to examine the sensitivity of Vibrio species to topical antimicrobial agents. Twenty-eight wound isolates were tested against the following eight topical preparations: silver sulfadiazine (Silvadene), nitrofurazone, mupirocin ointment (Bactroban), polymyxin B/bacitracin, mafenide acetate (Sulfamylon), nystatin/Silvadene, nystatin/polymyxin B/bacitracin, and 0.025% NaOCl solution. The results showed that V vulnificus, along with the other 18 Vibrio species tested, was most sensitive to the modified NaOCl solution.
我们报告了首例使用改良达金氏溶液（0.025%次氯酸钠[NaOCl]）阻止一名重症患者严重皮肤创伤弧菌感染进展的临床应用。所采用的治疗方案源自一项初步的体外研究，该研究旨在检测弧菌属对局部抗菌剂的敏感性。针对28株伤口分离菌株，测试了以下八种局部制剂：磺胺嘧啶银（Silvadene）、呋喃西林、莫匹罗星软膏（Bactroban）、多粘菌素B/杆菌肽、醋酸磺胺米隆（Sulfamylon）、制霉菌素/磺胺嘧啶银、制霉菌素/多粘菌素B/杆菌肽以及0.025% NaOCl溶液。结果显示，创伤弧菌以及所测试的其他18种弧菌属对改良NaOCl溶液最为敏感。
