Elmer K B, George R M
Flight Medicine Flight, Yokota Air Base, Japan.
Am Fam Physician. 1999 May 15;59(10):2809-13.
Cutaneous T-cell lymphoma, also known as mycosis fungoides, is a malignancy of the T helper (CD4+) cells. Diagnosis is difficult early in the course of this disease because it mimics several benign skin disorders, including eczema, psoriasis and contact dermatitis. Cutaneous T-cell lymphoma is also difficult to identify histologically, and multiple biopsies may be necessary to confirm the diagnosis. Treatment may require a combination of topical and systemic agents. Patients with limited skin disease have a good prognosis, but the prognosis is less hopeful in those with extracutaneous involvement. As the disease progresses, the normal T-cell population is eliminated, and the patient becomes significantly immunosuppressed. Infection is the primary cause of mortality in patients with cutaneous T-cell lymphoma.
皮肤T细胞淋巴瘤，也称为蕈样肉芽肿，是一种T辅助（CD4+）细胞的恶性肿瘤。在这种疾病的早期诊断很困难，因为它会模仿几种良性皮肤疾病，包括湿疹、银屑病和接触性皮炎。皮肤T细胞淋巴瘤在组织学上也难以识别，可能需要多次活检来确诊。治疗可能需要局部和全身药物联合使用。皮肤疾病局限的患者预后良好，但有皮肤外受累的患者预后则不太乐观。随着疾病进展，正常T细胞群体被清除，患者会出现明显的免疫抑制。感染是皮肤T细胞淋巴瘤患者死亡的主要原因。
