Nokes C, McGarvey S T, Shiue L, Wu G, Wu H, Bundy D A, Olds G R
Partnership for Child Development, Oxford University, United Kingdom.
Am J Trop Med Hyg. 1999 Apr;60(4):556-65. doi: 10.4269/ajtmh.1999.60.556.
A double-blind, placebo-controlled, treatment trial was conducted in Sichuan, China to investigate the unique and combined effects on the cognitive function (working memory) of children after treating geohelminth infections with albendazole and treating Schistosoma japonicum infection with praziquantel. One hundred eighty-one children 5-16 years of age participated. At baseline, the praziquantel and placebo groups were similar in all background characteristics. Three months after praziquantel treatment, there was a significant reduction in the prevalence and intensity of S. japonicum infection. There were significant age group by praziquantel treatment interaction effects in three of the five cognitive tests, Fluency, Picture Search, and Free Recall, with effects being strongest in the youngest children (5-7 years old). Exploratory analysis within the youngest children showed a significant positive main effect of treatment on Fluency (P < 0.001), after controlling for sex, anthropometric, and parasitic and iron status. There was also a treatment by height-for-age interaction (P = 0.03) and a treatment by iron status interaction (P = 0.024) on Fluency. There was a treatment by S. japonicum intensity interaction (P < 0.001) on Free Recall, but the main effect of treatment on Picture Search was not significant (P = 0.058). Younger children and those who are physically the most vulnerable are likely to benefit the most from the treatment of S. japonicum infection in terms of improved performance on tests of working memory.
在中国四川进行了一项双盲、安慰剂对照治疗试验，以研究用阿苯达唑治疗土源性蠕虫感染以及用吡喹酮治疗日本血吸虫感染后，对儿童认知功能（工作记忆）产生的独特及联合效应。181名5至16岁的儿童参与了试验。在基线时，吡喹酮组和安慰剂组在所有背景特征方面相似。吡喹酮治疗三个月后，日本血吸虫感染的患病率和感染强度显著降低。在五项认知测试中的三项，即流畅性、图片搜索和自由回忆测试中，存在吡喹酮治疗与年龄组的交互作用效应，在最年幼的儿童（5至7岁）中效应最为明显。对最年幼儿童进行的探索性分析显示，在控制了性别、人体测量指标、寄生虫感染及铁状态后，治疗对流畅性有显著的正向主效应（P < 0.001）。在流畅性方面还存在治疗与年龄别身高的交互作用（P = 0.03）以及治疗与铁状态的交互作用（P = 0.024）。在自由回忆测试中存在治疗与日本血吸虫感染强度的交互作用（P < 0.001），但治疗对图片搜索的主效应不显著（P = 0.058）。就工作记忆测试表现的改善而言，年幼的儿童以及身体最脆弱的儿童可能从日本血吸虫感染治疗中获益最大。
