委内瑞拉马脑炎病毒IE亚型基因型在中美洲和墨西哥的地理分布。

Geographic distribution of Venezuelan equine encephalitis virus subtype IE genotypes in Central America and Mexico.

作者信息

Oberste M S, Schmura S M, Weaver S C, Smith J F

机构信息

U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.

出版信息

Am J Trop Med Hyg. 1999 Apr;60(4):630-4. doi: 10.4269/ajtmh.1999.60.630.

DOI:10.4269/ajtmh.1999.60.630

PMID:10348239

Abstract

Phylogenetic analysis of 20 strains of Venezuelan equine encephalitis (VEE) virus subtype IE isolated from 1961 to 1996 in Mexico and throughout Central America showed that VEE virus subtype IE was monophyletic with respect to other VEE virus subtypes. Nonetheless, there were at least three distinct geographically separated VEE virus IE genotypes: northwestern Panama, Pacific coast (Mexico/Guatemala), and Gulf/Caribbean coast (Mexico/Belize). Strains from the Caribbean coast of Guatemala, Honduras, and Nicaragua may cluster with the Gulf/Caribbean genotype, but additional isolates from the region between Guatemala and Panama will be required to firmly establish their phylogenetic position. Viruses associated with two separate equine epizootics in Mexico in the 1990s were phylogenetically related to nonepizootic viruses from neighboring Guatemala and may represent the emergence or re-emergence of equine-virulent VEE virus subtype IE in Middle America.

摘要

对1961年至1996年在墨西哥及整个中美洲分离出的20株委内瑞拉马脑炎（VEE）病毒IE亚型进行系统发育分析表明，VEE病毒IE亚型相对于其他VEE病毒亚型是单系的。尽管如此，至少存在三种地理上分离的不同VEE病毒IE基因型：巴拿马西北部、太平洋沿岸（墨西哥/危地马拉）以及墨西哥湾/加勒比海沿岸（墨西哥/伯利兹）。来自危地马拉、洪都拉斯和尼加拉瓜加勒比海岸的毒株可能与墨西哥湾/加勒比海基因型聚类，但需要来自危地马拉和巴拿马之间地区的更多分离株来确定它们的系统发育位置。20世纪90年代在墨西哥与两次独立马疫情相关的病毒在系统发育上与来自邻国危地马拉的非疫情病毒相关，可能代表中美洲马烈性VEE病毒IE亚型的出现或再次出现。