Wise R, Andrews J M, Marshall G, Hartman G
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom.
Antimicrob Agents Chemother. 1999 Jun;43(6):1508-10. doi: 10.1128/AAC.43.6.1508.
A single 400-mg oral or intravenous (i.v.) dose of moxifloxacin was given to each of eight healthy male volunteers, and 6 weeks later the dose was administered by the other route. The concentrations of the drug in plasma, cantharidin-induced inflammatory fluid, and urine were measured over the subsequent 24 h. The mean maximum concentrations observed in plasma were 4.98 microg/ml after oral dosing and 5.09 microg/ml after i.v. dosing. The mean maximum concentrations attained in the inflammatory fluid were 2.62 and 3.23 microg/ml, respectively. The mean elimination half-lives from plasma were 8.32 and 8.17 h, respectively. The overall penetration into the inflammatory fluid was 103.4 and 104.2%. Over 24 h 15% of the drug was recovered in the urine when administered by either route.
给8名健康男性志愿者每人单次口服或静脉注射400毫克莫西沙星，6周后换用另一种给药途径。在随后的24小时内测定血浆、斑蝥素诱导的炎性液和尿液中的药物浓度。口服给药后血浆中观察到的平均最大浓度为4.98微克/毫升，静脉注射给药后为5.09微克/毫升。炎性液中达到的平均最大浓度分别为2.62和3.23微克/毫升。血浆中的平均消除半衰期分别为8.32和8.17小时。药物进入炎性液的总体渗透率分别为103.4%和104.2%。无论采用哪种给药途径，24小时内15%的药物可在尿液中回收。
