Willmore L J, Sypert G W, Munson J B
Ann Neurol. 1978 Oct;4(4):329-36. doi: 10.1002/ana.410040408.
A single injection of 5 or 10 microliters of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Iron-filled macrophages, ferruginated neurons, and astroglical cells surrounded the focus of seizure discharge. Recurrent focal epileptiform discharges caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on neurochemical alterations induced by the principal metallic ions found in whole blood.
向大鼠或猫的感觉运动皮层单次注射5或10微升氯化亚铁或氯化铁，会导致慢性复发性局灶性阵发性脑电图放电以及行为性惊厥和电惊厥。充满铁的巨噬细胞、含铁神经元和星形胶质细胞围绕着癫痫放电灶。皮层注射铁盐引起的复发性局灶性癫痫样放电表明，人类创伤后癫痫的发生可能部分取决于全血中主要金属离子引起的神经化学改变。
