Matsuura Y, Kashimura M, Hatanaka K, Toki N, Sugihara K
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Acta Cytol. 1999 May-Jun;43(3):475-80. doi: 10.1159/000331103.
Cytologic findings of sarcoma botryoides were still equivocal because sarcoma botryoides of the uterine cervix is an extremely rare neoplasm, and few cases have been reported to date.
A 17-year-old female was diagnosed with sarcoma botryoides of the uterine cervix. The entire vaginal canal was occupied with polypoid masses, which arose from the anterior lip of the uterine cervix, and the tumor was classified as group I (Intergroup Rhabdomyosarcoma Study). After wedge resection and six courses of combination chemotherapy, the tumor recurred in the same location of the cervix as the primary lesion. Touch smear of the polypoid mass formed loose clusters and also showed short spindle cells in a necrotic background. The nucleus of the tumor cells had a thin nuclear membrane, fine chromatin pattern and partly clear nucleolus, showing mild nuclear atypia. Immunohistochemically, some of the tumor cells showed positive staining for myoglobin and desmin.
The cytologic findings of sarcoma botryoides of the female genital tract are typical features of nonepithelial malignant tumor. Immunohistochemical study is useful for the diagnosis of rhabdomyosarcoma.
葡萄状肉瘤的细胞学表现仍不明确，因为宫颈葡萄状肉瘤是一种极其罕见的肿瘤，迄今为止报道的病例很少。
一名17岁女性被诊断为宫颈葡萄状肉瘤。整个阴道管被息肉样肿物占据，肿物起源于宫颈前唇，该肿瘤被归类为I组（横纹肌肉瘤协作组研究）。楔形切除并进行六个疗程的联合化疗后，肿瘤在宫颈与原发灶相同的位置复发。息肉样肿物的触摸涂片形成松散的细胞团，并且在坏死背景中也显示出短梭形细胞。肿瘤细胞核膜薄，染色质细腻，部分核仁清晰，显示轻度核异型性。免疫组化显示，部分肿瘤细胞肌红蛋白和结蛋白染色阳性。
女性生殖道葡萄状肉瘤的细胞学表现是非上皮性恶性肿瘤的典型特征。免疫组化研究对横纹肌肉瘤的诊断有帮助。
Zotero 插件