Grandel H, Schulte-Merker S
MPI für Entwicklungsbiologie, Tübingen, Germany.
Mech Dev. 1998 Dec;79(1-2):99-120. doi: 10.1016/s0925-4773(98)00176-2.
In the present study, we describe the structure and normal development of the zebrafish (Danio rerio) paired fins. Particularly, we focus on the structure of the apical epidermis and on endoskeletal morphogenesis. Endoskeletal development proceeds differently in the pectoral and pelvic fins. Whereas in both fins major parts of the endoskeletal girdle develop within the fin bud mesenchyme, the pattern of chondrogenic condensations observed in the pelvic fins directly reflects the adult endoskeletal pattern. In the pectoral fin, a morphogenetic detour is taken via a functional larval endoskeleton, the endoskeletal disc. It arises in the fin bud mesenchyme from a chondrogenic anlage common with the girdle. The disc chondrifies and represents the functional endoskeleton of the larval pectoral fin. The pectoral fin endoskeleton is expanded as well as restructured during larval stages in a process which involves decomposition of cartilage matrix in the endoskeletal disc. Our comparisons of apical fold morphology with reports on other teleosts and tetrapod apical ridges show them to be homologous on the structural level. Comparisons of endoskeletal development of the zebrafish with reports on teleosts, actinopterygians and chondrichthyans show that endoskeletal morphogenesis in the zebrafish pectoral fin follows a morphogenetic process which is wide-spread among actinopterygians.
在本研究中，我们描述了斑马鱼（Danio rerio）成对鳍的结构和正常发育。特别地，我们关注顶端表皮的结构和内骨骼形态发生。内骨骼在胸鳍和腹鳍中的发育过程不同。虽然在这两种鳍中，内骨骼带的主要部分在鳍芽间充质内发育，但在腹鳍中观察到的软骨形成凝聚模式直接反映了成体的内骨骼模式。在胸鳍中，通过功能性的幼体内骨骼——内骨骼盘，发生了形态发生迂回。它在鳍芽间充质中由与带共同的软骨形成原基产生。该盘软骨化并代表幼体胸鳍的功能性内骨骼。在幼体阶段，胸鳍内骨骼在一个涉及内骨骼盘软骨基质分解的过程中扩展并重构。我们将顶端褶皱形态与其他硬骨鱼和四足动物顶端嵴的报道进行比较，发现它们在结构水平上是同源的。将斑马鱼的内骨骼发育与硬骨鱼、辐鳍鱼和软骨鱼的报道进行比较表明，斑马鱼胸鳍的内骨骼形态发生遵循一种在辐鳍鱼中广泛存在的形态发生过程。
