肯娃娃和芭比娃娃基因位点处的一个转录单元编码一种新型果蝇锌指蛋白。

A transcription unit at the ken and barbie gene locus encodes a novel Drosophila zinc finger protein.

作者信息

Kühnlein R P, Chen C K, Schuh R

机构信息

Max-Planck-Institut für biophysikalische Chemie, Abt. Molekulare Entwicklungsbiologie, Göttingen, Germany.

出版信息

Mech Dev. 1998 Dec;79(1-2):161-4. doi: 10.1016/s0925-4773(98)00183-x.

DOI:10.1016/s0925-4773(98)00183-x

PMID:10349629

Abstract

We describe a novel Drosophila transcription unit, located in chromosome region 60A. It encodes a zinc finger protein that is expressed in distinct spatial and temporal patterns during embryogenesis. Its initial expression occurs in a stripe at the anterior and the posterior trunk boundary, respectively. The two stripes are activated and spatially controlled by gap-gene activities. The P-element of the enhancer trap line l(2)02970 is inserted in the 5'-region of the transcript and causes a ken and barbie (ken) phenotype, associated with malformation of male genital structures.

摘要

我们描述了一个位于60A染色体区域的新型果蝇转录单元。它编码一种锌指蛋白，该蛋白在胚胎发育过程中以不同的时空模式表达。其最初的表达分别出现在前躯干和后躯干边界的条带中。这两条带由间隙基因活性激活并在空间上受到控制。增强子陷阱系l(2)02970的P元件插入到转录本的5'区域，并导致与雄性生殖结构畸形相关的肯恩和芭比（ken）表型。