Gupta S, Bhargava K K, Novikoff P M
Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Semin Liver Dis. 1999;19(1):15-26. doi: 10.1055/s-2007-1007094.
Hepatocyte transplantation has excited much interest among investigators for applications in cell therapy and studies of fundamental mechanisms concerning liver biology. Progress in these areas has been greatly facilitated by the development of novel animal models. An understanding of early events during engraftment of transplanted cells is essential for optimal repopulation of the liver. Insights into how transplanted cells integrate in the parenchyma of the liver with reconstitution of specific plasma membrane structures is critical in devising therapeutic strategies for specific disorders. Moreover, these insights are necessary for understanding mechanisms concerning regulation of cell proliferation and gene expression in transplanted hepatocytes. Finally, analysis of the safety of cell transplantation is necessary for clinical applications of liver repopulation with cell transplantation. This review highlights selected advances in related areas concerning liver repopulation.
肝细胞移植在细胞治疗应用以及肝脏生物学基本机制研究方面引起了研究者们的浓厚兴趣。新型动物模型的开发极大地推动了这些领域的进展。了解移植细胞植入过程中的早期事件对于肝脏的最佳再填充至关重要。深入了解移植细胞如何与特定质膜结构的重建一起整合到肝脏实质中，对于设计针对特定疾病的治疗策略至关重要。此外，这些见解对于理解移植肝细胞中细胞增殖和基因表达的调控机制是必要的。最后，分析细胞移植的安全性对于细胞移植肝脏再填充的临床应用是必要的。本综述重点介绍了肝脏再填充相关领域的一些进展。
