Cohen D
Exp Aging Res. 1976 May;2(3):271-87. doi: 10.1080/03610737608257182.
The evidence for the hypothesis that an increased frequency of hypodiploid cells is related to mental status in older persons, as well as the underlying assumptions crucial to the hypothesis, are reviewed. Results of chromosome examinations reported by several independent laboratories favor an increasing proportion of hypodiploid cells in older age groups as well as sex differences in the level and distribution of missing chromosomes. However, the presence, extent, and development course of chromosome loss associated with major modifying variables and their interactions, e.g., age, morbidity, sex, environmental conditions, remain to be empirically documented. Furthermore, the meaning of chromosome loss, including its relationship to mental status, is not clear.
本文综述了关于亚二倍体细胞频率增加与老年人心理状态相关这一假说的证据，以及该假说至关重要的潜在假设。几个独立实验室报告的染色体检查结果表明，老年人群中亚二倍体细胞的比例增加，以及缺失染色体的水平和分布存在性别差异。然而，与主要调节变量及其相互作用（如年龄、发病率、性别、环境条件）相关的染色体丢失的存在、程度和发展过程仍有待实证记录。此外，染色体丢失的意义，包括其与心理状态的关系，尚不清楚。
