Hasegawa K
Nihon Yakurigaku Zasshi. 1976 Oct;72(7):827-35. doi: 10.1254/fpj.72.827.
A bipolar electrode was stereotaxically implanted in the substantia nigra of male albino Wistar-Imamichi rats. 1) Rats lifted and turned their heads and contralateral forelimb towards the contralateral side to the electrode during the substantia nigral self-stimulation (SS) behavior. 2) Methamphetamine facilitated the SS dose-dependently in the "threshold"-intensity reinforcement. The pretreatment of imipramine facilitated the effects of methamphetamine. 3) FLA63 and U-14,624, dopamine beta-hydroxylase inhibitors, suppressed the SS in the moderate-intensity reinforcement. 4) Apomorphine, stimulant of dopamine receptor, did not facilitate, but rather inhibited the SS dose-dependently in the "threshold"-intensity reinforcement. 5) l-Norepinephrine injected into the lateral ventricle facilitated the SS dose-dependently. On the other hand, dopamine had no marked effects. 6) These results suggest that the noradrenergic system in the brain plays a more important role in the positive reinforcement of the substantia nigral SS behavior than does the dopaminergicsystem.
将双极电极立体定向植入雄性白化Wistar-Imamichi大鼠的黑质中。1）在黑质自我刺激（SS）行为期间，大鼠将头部和对侧前肢抬起并转向电极对侧。2）在“阈值”强度强化中，甲基苯丙胺剂量依赖性地促进SS。丙咪嗪预处理可增强甲基苯丙胺的作用。3）多巴胺β-羟化酶抑制剂FLA63和U-14,624在中等强度强化中抑制SS。4）多巴胺受体激动剂阿扑吗啡在“阈值”强度强化中不促进而是剂量依赖性地抑制SS。5）注入侧脑室的去甲肾上腺素剂量依赖性地促进SS。另一方面，多巴胺没有明显作用。6）这些结果表明，大脑中的去甲肾上腺素能系统在黑质SS行为的正性强化中比多巴胺能系统起更重要的作用。
