Hasegawa K
Nihon Yakurigaku Zasshi. 1976 Nov;72(8):985-90. doi: 10.1254/fpj.72.985.
A bipolar electrode was stereotaxically implanted in the substantia nigra of male albino Wistar-Imamichi rats. Effects of l-norepinephrine (NE), dopamine (DA) and gamma-aminobutyric acid (GABA), injected into the lateral ventricle, on the substantia nigral self-stimulation (SS) behavior, and the effect of alpha- and beta-adrenergic receptor antagonists on the facilitation induced by NE were investigated. NE but not DA facilitated the SS behavior and GABA showed no constant effects on the behavior. Facilitation by NE of SS behavior was inhibited by phentolamine, but not by propranolol. These results suggest that the noradrenergic system in the brain may play a more significant role in the positive reinforcement of the substantia nigral SS behavior than does the dopaminergic or GABA-ergic system, and that the action of NE may be facilitated through alpha-receptors rather than through beta-receptors.
将双极电极立体定向植入雄性白化Wistar-Imamichi大鼠的黑质中。研究了向侧脑室注射左旋去甲肾上腺素（NE）、多巴胺（DA）和γ-氨基丁酸（GABA）对黑质自我刺激（SS）行为的影响，以及α和β肾上腺素能受体拮抗剂对NE诱导的促进作用的影响。NE促进了SS行为，而DA没有，GABA对该行为没有恒定影响。酚妥拉明可抑制NE对SS行为的促进作用，但普萘洛尔不能。这些结果表明，大脑中的去甲肾上腺素能系统在黑质SS行为的正强化中可能比多巴胺能或GABA能系统发挥更重要的作用，并且NE的作用可能通过α受体而不是β受体来促进。
