Wilkins K, Parsons G F, Gentleman J F, Forbes W F
Health Statistics Division, Statistics Canada, Ottawa, Ontario, K1A 0T6, Canada.
Chronic Dis Can. 1999;20(1):26-35.
This study analyzes multiple-cause-of-death information from over 113,000 death certificates of Canadians aged 65+ and identifies causes that are significantly likely and significantly unlikely to combine with dementia to cause death. For dementia as a mentioned cause and as the underlying cause of death, frequencies and rates of death were calculated. Dementia was mentioned on death certificates 2.4 times as often as it occurred as the underlying cause of death. Among the causes least associated with dementia were some cancers, chronic respiratory diseases and rheumatoid arthritis. Causes of death that rarely occur with dementia should be further investigated in terms of their potential role in preventing or delaying the onset of dementia. In particular, further study of the role of anti-inflammatory drugs and nicotine in reducing the risk of dementia is indicated. Causes positively associated with dementia largely reflect the physical deterioration it confers.
本研究分析了来自113,000多名65岁及以上加拿大居民死亡证明上的多死因信息，并确定了与痴呆症合并导致死亡显著可能和显著不可能的原因。对于作为提及死因和根本死因的痴呆症，计算了死亡频率和死亡率。死亡证明上提及痴呆症的频率是其作为根本死因出现频率的2.4倍。与痴呆症关联最小的死因包括某些癌症、慢性呼吸道疾病和类风湿性关节炎。对于很少与痴呆症同时发生的死因，应进一步研究其在预防或延缓痴呆症发病方面的潜在作用。特别是，有必要进一步研究抗炎药物和尼古丁在降低痴呆症风险方面的作用。与痴呆症呈正相关的死因在很大程度上反映了它所导致的身体衰退。
