Olszewski A D, Jones R, Farrell R, Kaylor K
Department of Orthopaedic Surgery, Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA.
Am J Sports Med. 1999 May-Jun;27(3):354-6. doi: 10.1177/03635465990270031501.
A prospective, randomized, double-blinded study was performed to determine whether dilute epinephrine saline irrigation (1 mg/l) delivered by gravity flow would significantly reduce the need for tourniquet use during routine arthroscopic surgery. One hundred five patients requiring straightforward arthroscopic knee surgery were randomly assigned to either an epinephrine group that received dilute epinephrine irrigation by gravity flow or to a placebo group that received normal saline irrigation by gravity flow. The need for tourniquet use and the tourniquet time, total operative time, and volume of irrigation fluid used were documented and compared between the two groups. A tourniquet was required 50% less often in the epinephrine group than in the placebo group. This difference was found to be statistically significant using the Student's t-test (P < 0.008, alpha < or = 0.05). If a tourniquet was required, the presence of dilute epinephrine in the irrigation fluid did not affect the overall tourniquet time or the ratio of tourniquet time to total operative time. We believe this study proved that dilute epinephrine irrigation is effective in decreasing the need for tourniquet use during routine arthroscopic knee surgery.
进行了一项前瞻性、随机、双盲研究，以确定重力流输送的稀释肾上腺素盐水冲洗液（1毫克/升）是否能显著减少常规关节镜手术中使用止血带的需求。105例需要进行简单关节镜膝关节手术的患者被随机分为肾上腺素组（通过重力流接受稀释肾上腺素冲洗）或安慰剂组（通过重力流接受生理盐水冲洗）。记录并比较两组使用止血带的需求、止血带使用时间、总手术时间和冲洗液用量。肾上腺素组使用止血带的频率比安慰剂组低50%。使用学生t检验发现这种差异具有统计学意义（P<0.008，α≤0.05）。如果需要使用止血带，冲洗液中稀释肾上腺素的存在并不影响总的止血带使用时间或止血带使用时间与总手术时间的比例。我们认为这项研究证明，稀释肾上腺素冲洗在减少常规关节镜膝关节手术中使用止血带的需求方面是有效的。
