Liberg D, Sigvardsson M
Department of Cellular and Molecular Biology, Immunology Group, Lund University, Sweden.
Crit Rev Immunol. 1999;19(2):127-53.
B cell development is a multistage differentiation process that ultimately generates antibody-secreting plasma cells. This model developmental pathway is governed by a choreographed pattern of expression from genes encoding stage and lineage-specific proteins. This is achieved by the interaction of distinct transcription factors with regulatory elements, placing these proteins in a central position in B cell ontogeny. The importance of distinct transcription factors is also supported by the notion that B cell development is disrupted in mice bearing homozygous null alleles of certain factors involved in the control of B-cell-specific genes. In this review we compare and contrast the transcriptional regulation of well-studied B lymphoid restricted genes, on a gene by gene basis, focusing on the functional structure of transcription control regions and interacting transcription factors.
B细胞发育是一个多阶段的分化过程，最终产生分泌抗体的浆细胞。这种典型的发育途径由编码阶段和谱系特异性蛋白的基因所编排的表达模式所调控。这是通过不同转录因子与调控元件的相互作用实现的，这些蛋白在B细胞个体发育中处于核心地位。B细胞发育在携带某些参与B细胞特异性基因控制的因子纯合无效等位基因的小鼠中受到破坏，这一观点也支持了不同转录因子的重要性。在本综述中，我们逐基因地比较和对比了经过充分研究的B淋巴细胞限制性基因的转录调控，重点关注转录控制区的功能结构和相互作用的转录因子。
