Debette M, Samuel D, Ichai P, Sebagh M, Saliba F, Bismuth H
Centre Hépato-Biliaire, Hôpital Paul-Brousse, Université Paris-Sud, Villejuif.
Gastroenterol Clin Biol. 1999 Feb;23(2):264-7.
Liver disease is a rare complication of pregnancy which can be serious for both the mother and the infant. In particular, HELLP syndrome (hemolysis, elevated liver enzymes and a low platelet count) is a life threatening complication of severe preeclampsia. Pregnancies complicated by the HELLP syndrome are usually associated with increased maternal and perinatal morbidity and mortality including disseminated intravascular coagulopathy, pulmonary and cerebral oedema, acute renal failure, rupture of the liver hematoma and a variety of hemorrhagic complications. The HELLP syndrome occurs in 4 to 12% of patients with severe preeclampsia and prompt delivery is the only treatment. We report two cases of HELLP syndrome which developed in women during delivery and without any predictive factors during pregnancy.
肝病是妊娠的一种罕见并发症，对母亲和婴儿都可能很严重。特别是，HELLP综合征（溶血、肝酶升高和血小板计数低）是重度子痫前期的一种危及生命的并发症。合并HELLP综合征的妊娠通常与孕产妇和围产期发病率及死亡率增加相关，包括弥散性血管内凝血、肺水肿和脑水肿、急性肾衰竭、肝血肿破裂以及各种出血并发症。HELLP综合征发生在4%至12%的重度子痫前期患者中，迅速分娩是唯一的治疗方法。我们报告了两例在分娩期间发生且孕期无任何预测因素的HELLP综合征病例。
