Serhan C N, Takano T, Gronert K, Chiang N, Clish C B
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Clin Chem Lab Med. 1999 Mar;37(3):299-309. doi: 10.1515/CCLM.1999.052.
Eicosanoids are known to play important roles in inflammation. Recent findings have given rise to several new concepts regulating the generation of eicosanoids, illustrated in Figure 1. Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within vascular lumen by platelet-leukocyte interactions and at mucosal surfaces by leukocyte-epithelial cell interactions. During these cell-cell interactions, transcellular biosynthetic pathways are used as major routes, and thus, in humans, LX are formed in vivo during multicellular responses such as inflammation, atherosclerosis, and thrombosis. This branch of the eicosanoid cascade generates specific tetraene-containing products that appear to function as stop signals, since they inhibit key steps in leukocyte-mediated inflammation. Of special interest, it appears that aspirin also functions in part via production of novel epimers of lipoxins or 15-epi-lipoxins (Figure 1). Here, we review recent developments on the cellular interactions of these novel anti-inflammatory mediators.
类二十烷酸在炎症中发挥重要作用。最近的研究结果产生了几个调节类二十烷酸生成的新概念，如图1所示。脂氧素（LX）是含有三羟基四烯的类二十烷酸，通过血小板 - 白细胞相互作用在血管腔内产生，并通过白细胞 - 上皮细胞相互作用在粘膜表面产生。在这些细胞间相互作用过程中，跨细胞生物合成途径被用作主要途径，因此，在人类中，LX在多细胞反应如炎症、动脉粥样硬化和血栓形成过程中在体内形成。类二十烷酸级联反应的这一分支产生特定的含四烯产物，这些产物似乎起到停止信号的作用，因为它们抑制白细胞介导的炎症中的关键步骤。特别有趣的是，阿司匹林似乎也部分通过产生脂氧素的新型差向异构体或15-表脂氧素（图1）发挥作用。在此，我们综述这些新型抗炎介质细胞间相互作用的最新进展。
