Wilson K, Whyman M, Hoskins P, Lee A J, Bradbury A W, Fowkes F G, Ruckley C V
Vascular Surgery Unit, University of Edinburgh, Royal Infirmary of Edinburgh, UK.
Cardiovasc Surg. 1999 Mar;7(2):208-13. doi: 10.1016/s0967-2109(98)00041-6.
Aortic compliance as measured by the pressure-strain elastic modulus (Ep) and stiffness (beta), may allow a more precise estimate of rupture risk. The aim of this study was to determine the relationships between compliance, maximal aneurysm diameter and growth rate.
Sixty abdominal aortic aneurysm patients of median age 73 years, were studied. Growth rate was derived from repeat ultrasound scans obtained over a median period of 21 months (range 6-48). At the end of follow-up, patients underwent measurement of maximum aortic diameter, Ep and beta using the Diamove echo-tracking system.
Growth rate correlated positively (r = 0.6, P < 0.01) with maximum diameter on entry to the study There was a positive correlation between mean arterial pressure and Ep (r = 0.3, P = 0.03), but not between mean arterial pressure and beta (r = 0.8, P = 0.61). A positive correlation was found between final maximum diameter and Ep (r = 0.22, P = 0.04) but not beta (r = 0.16, P = 0.11). There was no significant relationship between growth rate and Ep or beta.
Large aneurysms tended to be less compliant. Within a population of abdominal aortic aneurysm of similar maximum diameter there was a 10-fold variation in Ep and beta. Compliance and growth rate were not related. If aortic compliance is related to risk of rupture then this predictive information is likely to be largely independent of that currently obtained from size and growth rate.
通过压力-应变弹性模量（Ep）和硬度（β）测量的主动脉顺应性，可能会更精确地估计破裂风险。本研究的目的是确定顺应性、最大动脉瘤直径和生长速率之间的关系。
对60例腹主动脉瘤患者进行了研究，中位年龄73岁。生长速率来自于在中位时间21个月（范围6 - 48个月）内重复进行的超声扫描。随访结束时，使用Diamove回声跟踪系统对患者进行最大主动脉直径、Ep和β的测量。
生长速率与研究入组时的最大直径呈正相关（r = 0.6，P < 0.01）。平均动脉压与Ep之间存在正相关（r = 0.3，P = 0.03），但平均动脉压与β之间无相关性（r = 0.8，P = 0.61）。最终最大直径与Ep之间存在正相关（r = 0.22，P = 0.04），但与β无相关性（r = 0.16，P = 0.11）。生长速率与Ep或β之间无显著关系。
大动脉瘤的顺应性往往较低。在最大直径相似的腹主动脉瘤人群中，Ep和β存在10倍的差异。顺应性与生长速率无关。如果主动脉顺应性与破裂风险相关，那么这种预测信息可能在很大程度上独立于目前从大小和生长速率获得的信息。
