Houghton J, Korah R M, Kim K H
UMDNJ-New Jersey Medical School, Department of Microbiology and Molecular Genetics, Newark, NJ 07103, USA.
J Infect Dis. 1999 Jul;180(1):211-5. doi: 10.1086/314832.
Activation of the Fas-mediated apoptotic pathway in the etiology of idiopathic esophageal ulcerations (IEUs) was investigated. Constitutive expression of Fas ligand (Fas L) was found in the basal layer of the normal esophageal mucosa and in IEUs and cytomegalovirus ulcerations. In addition to an altered cytokine environment, there was significant up-regulation of Fas antigen mRNA and membrane localization of the receptor in IEU specimens. Concomitant increase in the basic components of Fas machinery, together with elevated mucosal apoptosis, strongly suggests the potential role of the Fas signaling pathway in the onset of tissue destruction associated with IEUs.
研究了Fas介导的凋亡途径在特发性食管溃疡（IEU）病因中的激活情况。在正常食管黏膜的基底层、IEU和巨细胞病毒溃疡中发现了Fas配体（Fas L）的组成性表达。除了细胞因子环境改变外，IEU标本中Fas抗原mRNA显著上调，且受体定位于细胞膜。Fas机制的基本成分同时增加，以及黏膜凋亡增加，强烈提示Fas信号通路在与IEU相关的组织破坏发生中具有潜在作用。
