Joseph E M, Cassetta L A
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Mech Dev. 1999 Apr;82(1-2):191-4. doi: 10.1016/s0925-4773(99)00010-6.
We have isolated a novel gene from Xenopus, called Mespo, which encodes a protein containing a basic helix-loop-helix (bHLH) motif characteristic of a family of transcriptional activators. Mespo expression begins at the gastrula stage and continues throughout tailbud stages; expression occurs in the presomitic mesoderm and the posterior tailbud. Mespo has high similarity to a subfamily of bHLH transcription factors involved in segmentation of the presomitic paraxial mesoderm.
我们从非洲爪蟾中分离出一个名为Mespo的新基因，它编码一种含有碱性螺旋-环-螺旋（bHLH）基序的蛋白质，该基序是转录激活因子家族的特征。Mespo的表达始于原肠胚阶段，并在整个尾芽阶段持续；表达发生在体节形成前的中胚层和尾芽后部。Mespo与参与体节形成前轴旁中胚层分割的bHLH转录因子亚家族具有高度相似性。
